Epidiolex and Verapamil Immediate-Release Tablets
Determining the interaction of Epidiolex and Verapamil Immediate-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Verapamil may increase the blood levels of cannabidiol. This may increase side effects such as drowsiness, diarrhea, decreased appetite, and liver problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with moderate or potent inhibitors of CYP450 2C19 and/or CYP450 3A4 may increase the plasma concentrations of cannabidiol, which is primarily metabolized by these isoenzymes in the liver and gut.
MANAGEMENT: Dosage reduction of cannabidiol should be considered when coadministered with moderate or potent inhibitors of CYP450 2C19 and/or CYP450 3A4.
- "Product Information. Epidiolex (cannabidiol)." Greenwich Biosciences Inc, Carlsbad, CA.
Generic Name: cannabidiol
Brand name: Epidiolex
Synonyms: Epidiolex Oral Solution
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Epidiolex-Verapamil Injection
- Epidiolex-Verapamil Intravenous
- Epidiolex-Verapamil Long-Acting Capsules
- Epidiolex-Verapamil Long-Acting Tablets
- Epidiolex-Verapamil oral/injection
- Epidiolex-Verapamil Sustained-Release Capsules
- Verapamil Immediate-Release Tablets-Epidiolex Oral Solution
- Verapamil Immediate-Release Tablets-Epiduo
- Verapamil Immediate-Release Tablets-Epiduo Forte
- Verapamil Immediate-Release Tablets-Epifoam
- Verapamil Immediate-Release Tablets-Epiject Iv
- Verapamil Immediate-Release Tablets-Epiklor