Eplerenone and Miconazole (Oral)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Miconazole may increase the blood levels and effects of eplerenone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 including azole antifungal agents may increase the plasma concentrations of eplerenone, which is primarily metabolized by the isoenzyme. In pharmacokinetic studies, administration of eplerenone (100 mg single dose) with the potent inhibitor ketoconazole (200 mg twice a day) resulted in a 1.7-fold increase in eplerenone peak plasma concentration (Cmax) and a 5.4-fold increase in systemic exposure (AUC), while administration with other 3A4 inhibitors (erythromycin 500 mg twice daily; verapamil 240 mg once daily; saquinavir 1200 mg three times daily; fluconazole 200 mg once daily) resulted in increases in eplerenone Cmax ranging from 1.4- to 1.6-fold and AUC from 2.0 to 2.9-fold. The interaction has not been studied with miconazole buccal tablets. Although systemic absorption following mucous membrane exposure is limited, the potential for interaction with drugs metabolized by CYP450 3A4 such as eplerenone cannot be ruled out.

MANAGEMENT: Caution is advised if eplerenone is prescribed in combination with miconazole mucous membrane preparations. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever miconazole is added to or withdrawn from therapy.

Eplerenone

Generic Name: eplerenone

Brand name: Inspra

Synonyms: n.a.

What is Eplerenone?

Miconazole (Oral)

Generic Name: miconazole

Brand name: Oravig, Monistat IV, Oravig

Synonyms: Miconazole oral (buccal)

What is Miconazole (Oral)?