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Epoprostenol and Sinarest

Determining the interaction of Epoprostenol and Sinarest and the possibility of their joint administration.

Check result:

Epoprostenol <> Sinarest

Relevance: 02.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using pseudoephedrine together with epoprostenol. Using these medications together can make epoprostenol less effective. You should be counseled to consult with your doctor before taking over-the-counter decongestants. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent administration of decongestants or vasoconstrictors may negate the vasodilatory effects of prostacyclin analogs in patients with pulmonary hypertension.

MANAGEMENT: The use of decongestants and vasoconstrictors should probably be avoided in patients with pulmonary hypertension. Patients should be counseled to consult with their physician before taking over-the-counter decongestants such as phenylephrine and pseudoephedrine.

References

Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
"Product Information. Remodulin (treprostinil)." United Therapeutics Corp, Silver Spring, MD.
"Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.

Epoprostenol

Generic Name: epoprostenol

Brand name: Flolan, Veletri

Synonyms: n.a.

What is Epoprostenol?

Sinarest

Generic Name: acetaminophen / chlorpheniramine / pseudoephedrine

Brand name: Complete Sinus Relief, Sinadrin PE Complete Sinus Relief, Alka-Seltzer Plus Cold Liquigel, Allerest Headache Strength, Allerest Sinus, Cold Medicine Plus, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Kolephrin, Sinarest, Sinutab Ex-Strength, Theraflu Cold & Sore Throat, Theraflu Flu & Sore Throat, Theraflu Maximum Strength, Singlet, Simplet, Tricom, Theraflu Flu and Cold Medicine Powder, Codimal, Tylenol Gelcap Allergy Sinus, Theraflu Sore Throat Maximum Strength, Tylenol Cold-Child, Tylenol Allergy Sinus Caplet, Tylenol Allergy Sinus Geltab, Sinarest Extra Strength, Children's Tylenol Cold Multi-Symptom, Tylenol Allergy Sinus Gelcap, Children's Tylenol Cold, Triaminicin, Sinutab Maximum Strength Caplets, Sinutab Maximum Strength Non-Drowsy, Actifed Cold & Sinus, Allergy Sinus Maximum Strength, EQ Cold Plus

Synonyms: n.a.

What is Sinarest?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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