Epoprostenol Sodium and Orudis KT
Determining the interaction of Epoprostenol Sodium and Orudis KT and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using epoprostenol together with ketoprofen can increase the risk of bleeding. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Prostacyclin/prostacyclin analogs (e.g., epoprostenol, iloprost, treprostinil) inhibit platelet aggregation and may theoretically potentiate the risk of bleeding in patients treated with other agents that affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. In clinical trials for pulmonary hypertension, patients received concomitant anticoagulants and/or nonsteroidal anti-inflammatory agents without evidence of increased bleeding.
MANAGEMENT: Caution is advised if prostacyclin and prostacyclin analogs are used in combination with other drugs that affect hemostasis. Close clinical and laboratory observation for hemorrhagic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.
- "Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Remodulin (treprostinil)." United Therapeutics Corp, Silver Spring, MD.
Generic Name: epoprostenol
Brand name: Flolan, Veletri
Synonyms: Epoprostenol
Generic Name: ketoprofen
Brand name: Oruvail, Orudis, Actron, Orudis KT
Synonyms: Orudis KT (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Epoprostenol Sodium-Oruvail
- Epoprostenol Sodium-Orvaten
- Epoprostenol Sodium-Os-Cal 500+D
- Epoprostenol Sodium-Os-Cal 500+Extra D Chewable
- Epoprostenol Sodium-Os-Cal Extra D3
- Epoprostenol Sodium-Oscimin (Hyoscyamine Orally Disintegrating Tablets)
- Orudis KT-Eposin
- Orudis KT-Eprosartan
- Orudis KT-Eprosartan and Hydrochlorothiazide
- Orudis KT-Eprosartan Mesylate
- Orudis KT-Epsal
- Orudis KT-Epsom Salt