Equaline Acid Reducer and Junel Fe 1.5/30

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Theoretically, pharmacologic effects of estrogens may be enhanced during treatment with cimetidine due to increased serum concentrations of endogenous estradiol. The mechanism is cimetidine inhibition of the 2-hydroxylation of estradiol. In nine healthy male volunteers, the mean percentage of estradiol 2-hydroxylation decreased by 25% during a cimetidine infusion (300 mg once followed by 50 mg/hr) and by nearly 40% following two weeks of oral cimetidine (800 mg twice a day), the latter accompanied by a 20% increase in serum estradiol concentration. The interaction was also demonstrated with a lower dosage of cimetidine (400 mg orally twice a day for one week). In another study, estradiol 2-hydroxylation decreased by nearly 30% in nine premenopausal women after one month of cimetidine (800 mg orally twice a day), but there was no change in serum estradiol levels (follicular phase). In contrast, estradiol 2-hydroxylation decreased by one-half and serum estradiol levels doubled in five postmenopausal women after one month of cimetidine treatment (600 mg orally twice a day for 2 weeks, followed by 1200 mg twice a day). The clinical significance of these changes is unknown. Ranitidine (150 mg twice a day) has been shown to have no effect on estradiol metabolism or serum levels.

Equaline Acid Reducer

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Equaline Acid Reducer?

Junel Fe 1.5/30

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

What is Junel Fe 1.5/30?