Equaline Acid Reducer and Vfend
Determining the interaction of Equaline Acid Reducer and Vfend and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with cimetidine may slightly increase the plasma concentrations of voriconazole. In 12 healthy male subjects, cimetidine (400 mg every 12 hours for 8 days) increased the steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of voriconazole (200 mg orally every 12 hours for 7 days) by an average of 18% and 23%, respectively, compared to placebo. Cimetidine had no effect on the half-life of voriconazole. In addition, adverse events were similar during coadministration with cimetidine or placebo. No particular action or caution is required, as this interaction is unlikely to be of clinical significance.
- Purkins L, Wood N, Kleinermans D, Nichols D "Histamine H2-receptor antagonists have no clinically significant effect on the steady-state pharmacokinetics of voriconazole." Br J Clin Pharmacol 56 Suppl 1 (2003): 51-5
- "Product Information. VFEND (voriconazole)." Pfizer U.S. Pharmaceuticals, New York, NY.
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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