Equaline Nicotine Lozenge and Pepcid AC Chewable Tablets
Determining the interaction of Equaline Nicotine Lozenge and Pepcid AC Chewable Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol 38 (1990): 165-9
Generic Name: nicotine
Brand name: Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Commit, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ, Nicotrol Inhaler, Nicotrol NS
Synonyms: Nicotine Gum and Lozenges, Nicotine
Generic Name: famotidine
Brand name: Pepcid AC Chewable Tablets, Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid Oral Suspension
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Equaline Nicotine Lozenge-Pepcid AC Maximum Strength
- Equaline Nicotine Lozenge-Pepcid Complete
- Equaline Nicotine Lozenge-Pepcid Oral Suspension
- Equaline Nicotine Lozenge-Peptic Relief
- Equaline Nicotine Lozenge-Pepto-Bismol
- Equaline Nicotine Lozenge-Pepto-Bismol (Bismuth Subsalicylate Chewable Tablets)
- Pepcid AC Chewable Tablets-Equaline Sleep Aid
- Pepcid AC Chewable Tablets-Equate Acid Controller Maximum Strength
- Pepcid AC Chewable Tablets-Equate Dual Action Complete
- Pepcid AC Chewable Tablets-Equate Mini Nicotine Lozenge - Fast Dissolving - Mint
- Pepcid AC Chewable Tablets-Equate Nicotine Lozenge
- Pepcid AC Chewable Tablets-Equate Sleep Aid