Equetro and Eslicarbazepine Acetate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with eslicarbazepine may increase the risk of certain side effects such as dizziness, drowsiness, abnormal coordination, and double vision or other visual disturbances. In addition, carBAMazepine can reduce the blood levels of eslicarbazepine, which may make it less effective in treating your condition. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with carbamazepine may increase the risk of some adverse effects associated with eslicarbazepine such as dizziness, diplopia, and abnormal coordination. In controlled trials, dizziness was reported in 30% versus 11.5%, diplopia in 11.4% versus 2.4%, and abnormal coordination in 6.7% versus 2.7% of subjects receiving eslicarbazepine acetate with carbamazepine and without carbamazepine, respectively. The potential for increased risk of other specific adverse reactions should be considered. Pharmacokinetically, carbamazepine may reduce the plasma concentrations of eslicarbazepine. In healthy study subjects, eslicarbazepine systemic exposure (AUC) decreased by an average of 32% when eslicarbazepine acetate 800 mg once daily was coadministered with carbamazepine 400 mg twice daily. The proposed mechanism is carbamazepine induction of the glucuronidation of eslicarbazepine. No changes were observed in the AUC of carbamazepine or its metabolite, carbamazepine-epoxide.

MANAGEMENT: When eslicarbazepine acetate is coadministered with carbamazepine, dosage modifications for one or both drugs may be required based on efficacy and tolerability. Patients should be closely monitored for dose-related adverse reactions such as dizziness, ataxia, vertigo, gait disturbance, nystagmus, and abnormal coordination, particularly during the titration period and in patients 60 years of age and older.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Eslicarbazepine Acetate

Generic Name: eslicarbazepine

Brand name: Aptiom

Synonyms: Eslicarbazepine

What is Eslicarbazepine Acetate?