Equetro and Nefazodone Hydrochloride
Determining the interaction of Equetro and Nefazodone Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carBAMazepine together with nefazodone is not recommended. Combining these medications can alter the blood levels and effects of both medications. Specifically, nefazodone levels may significantly decrease, which may make the medication ineffective in treating your condition. At the same time, carBAMazepine levels may increase, and you may experience more frequent and/or severe side effects such as headache, nausea, vomiting, dizziness, confusion, slurred speech, visual disturbances, tremors and/or incoordination. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration of carbamazepine and nefazodone may result in significantly decreased plasma concentrations of nefazodone and its active metabolite, hydroxynefazodone, and increased plasma concentrations of carbamazepine. The proposed mechanism is carbamazepine induction of nefazodone and hydroxynefazodone metabolism via CYP450 3A4, and nefazodone inhibition of carbamazepine metabolism via the same isoenzyme. In 12 healthy subjects administered carbamazepine 200 mg twice daily with nefazodone 200 mg twice daily to steady state, an approximately 85% reduction in peak plasma concentration (Cmax) and nearly 95% reduction in systemic exposure (AUC) were reported for both nefazodone and hydroxynefazodone, which would likely lead to therapeutic failure in a clinical setting. Carbamazepine Cmax and AUC were increased by 23%. Case reports have described carbamazepine toxicity following the initiation of nefazodone therapy, necessitating a reduction in carbamazepine dosage or discontinuation of nefazodone.
MANAGEMENT: Concomitant use of nefazodone and carbamazepine is considered contraindicated.
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- Laroudie C, Salazar DE, Cosson JP, Cheuvart B, Istin B, Girault J, Ingrand I, Decourt JP "Carbamazepine-nefazodone interaction in healthy subjects." J Clin Psychopharmacol 20 (2000): 46-53
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: n.a.
Generic Name: nefazodone
Brand name: Serzone
Synonyms: Nefazodone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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