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Equetro and Ofev

Determining the interaction of Equetro and Ofev and the possibility of their joint administration.

Check result:

Equetro <> Ofev

Relevance: 23.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

CarBAMazepine may significantly reduce the blood levels of nintedanib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with inducers of P-glycoprotein (P-gp) and CYP450 3A4 may decrease the plasma concentrations of nintedanib, which is a substrate of the efflux transporter and a minor substrate of the isoenzyme. In a dedicated drug interaction study, administration of nintedanib with the potent P-gp and CYP450 3A4 inducer, rifampin, decreased nintedanib peak plasma concentration (Cmax) and systemic exposure (AUC) by 40% and 50%, respectively, compared to administration of nintedanib alone. No data are available for use with other, less potent inducers.

MANAGEMENT: Concomitant use of nintedanib with P-gp and CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.

References

"Product Information. Ofev (nintedanib)." Boehringer Ingelheim, Ridgefield, CT.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Ofev

Generic Name: nintedanib

Brand name: Ofev

Synonyms: n.a.

What is Ofev?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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