Equetro and Palbociclib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using palbociclib together with carBAMazepine is not recommended. Combining these medications may significantly reduce the blood levels of palbociclib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of palbociclib, which is a substrate of the isoenzyme. In 15 healthy study subjects, administration of a single 125 mg dose of palbociclib with multiple 600 mg daily doses of rifampin, a potent CYP450 3A4 inducer, resulted in 70% and 85% decreases in palbociclib peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to palbociclib administered alone. Therapeutic failure may occur.

MANAGEMENT: Concomitant use of palbociclib with potent CYP450 3A4 inducers should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Palbociclib

Generic Name: palbociclib

Brand name: Ibrance

Synonyms: n.a.

What is Palbociclib?