Equetro and Rufinamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with certain antiepileptic agents (carbamazepine, phenobarbital, phenytoin, primidone, vigabatrin) has been shown to decrease the plasma concentrations of rufinamide. The mechanism of interaction is unknown, since the majority of rufinamide clearance is via a non-CYP450 pathway. In pharmacokinetic studies, carbamazepine reduced the concentrations of rufinamide by 19% to 26% in a dose-dependent manner. Phenobarbital, phenytoin, and primidone reduced the concentrations of rufinamide by 25% to 46%, and these alterations were not dependent on dose of the antiepileptic agent. In general, rufinamide had little effect on the pharmacokinetics of other antiepileptic agents. Any effects, when they occurred, have been more marked in the pediatric population.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Rufinamide

Generic Name: rufinamide

Brand name: Banzel

Synonyms: n.a.

What is Rufinamide?