Equetro and Sertraline

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may decrease the blood levels and effects of sertraline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of carbamazepine with sertraline may result in a reduction in the plasma concentrations and therapeutic effects of sertraline. The proposed mechanism is carbamazepine induction of CYP450 3A4-mediated metabolism of sertraline. It cannot be excluded that other CYP450 3A4 inducers (e.g., phenytoin, phenobarbital (phenobarbitone), rifampin, St. John's wort) may also cause a reduction of sertraline plasma levels. In addition, it is possible that central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking carbamazepine and sertraline, especially in elderly or debilitated patients.

MANAGEMENT: The potential for diminished therapeutic effects of sertraline should be considered when prescribed in combination with carbamazepine. Patients should be closely monitored, and the dosage of sertraline adjusted as necessary. Data are not available to guide dosing of sertraline when coadministered with potent CYP450 3A4 inducers. Alternative agents with no or minimal CYP450 3A4-inducing activity may also be considered. In addition, during concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their doctor if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Sertraline

Generic Name: sertraline

Brand name: Zoloft

Synonyms: n.a.

What is Sertraline?