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Equetro and Sirturo Tablets

Determining the interaction of Equetro and Sirturo Tablets and the possibility of their joint administration.

Check result:

Equetro <> Sirturo Tablets

Relevance: 23.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using bedaquiline together with carBAMazepine. Combining these medications may reduce the blood levels of bedaquiline, which may decrease its effectiveness in treating tuberculosis. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent or moderate inducers of CYP450 3A4 may decrease the plasma concentrations of bedaquiline, which is primarily metabolized by CYP450 3A4 to the major N-monodesmethyl metabolite, M2. Because M2 is 4- to 6-fold less active than the parent drug in terms of antimycobacterial potency, the interaction may diminish the therapeutic effect of bedaquiline. In healthy volunteers, administration of a single 300 mg dose of bedaquiline in combination with rifampin 600 mg once daily for 21 days reduced bedaquiline systemic exposure (AUC) by 52% compared to administration alone. Another study involving healthy volunteers revealed a 20% decrease in the AUC and no change in the Cmax of bedaquiline (400 mg once) when administered with efavirenz (600 mg once daily for 27 days).

MANAGEMENT: The concomitant use of bedaquiline with potent or moderate CYP450 3A4 inducers should generally be avoided.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Sirturo (bedaquiline)." Janssen Pharmaceuticals, Titusville, NJ.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Sirturo Tablets

Generic Name: bedaquiline

Brand name: Sirturo

Synonyms: Bedaquiline, Bedaquiline Fumarate

What is Sirturo Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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