Equetro and Symproic

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may significantly reduce the blood levels of naldemedine, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of naldemedine, which is primarily metabolized by CYP450 3A4 to nor-naldemedine and to a minor extent by UGT1A3 to naldemedine 3-G. Both metabolites have demonstrated antagonistic activity for opioid receptors, but with less potency than the parent drug. According to the product labeling, administration of naldemedine with 600 mg once daily rifampin, a potent CYP450 3A4 inducer, decreased naldemedine peak plasma concentration (Cmax) by 38% and systemic exposure (AUC) by 83% compared to naldemedine administered alone. Induction of P-glycoprotein efflux transporter by rifampin may have also contributed to the interaction.

MANAGEMENT: Concomitant use of naldemedine with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Symproic

Generic Name: naldemedine

Brand name: Symproic

Synonyms: n.a.

What is Symproic?