Equetro and Tasigna

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may significantly reduce the blood levels of nilotinib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of nilotinib, which is primarily metabolized by the isoenzyme. In healthy subjects receiving the potent inducer rifampin (600 mg once daily for 12 days), nilotinib systemic exposure (AUC) was decreased approximately 80%. Data are not available for nilotinib in combination with other, less potent CYP450 3A4 inducers.

MANAGEMENT: Concomitant use of nilotinib with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy. If coadministration is required, a dosage increase for nilotinib may be necessary depending on patient tolerability. The dosage should be reduced to the indicated dosage following discontinuation of the potent CYP450 3A4 inducer.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Tasigna

Generic Name: nilotinib

Brand name: Tasigna

Synonyms: n.a.

What is Tasigna?