Equetro and Teniposide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using carBAMazepine together with teniposide may decrease the effects of teniposide. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Some anticonvulsants such as carbamazepine, phenobarbital, phenytoin, and primidone may reduce the systemic exposure of teniposide. The proposed mechanism is accelerated clearance of teniposide due to induction of hepatic CYP450 enzymes by these anticonvulsants. In one study, the systemic clearance of teniposide in six pediatric patients receiving concomitant therapy with either phenobarbital or phenytoin was consistently increased two- to threefold compared to that in a matched control group of patients receiving the same chemotherapeutic protocol without anticonvulsant therapy (mean 32 mL/min/m2 vs. 13 mL/min/m2). The investigators noted that clearance estimates for control patients were similar to previously published values for pediatric patients. The investigators also studied one patient who demonstrated a similar change in teniposide clearance rate following coadministration of carbamazepine. Based on these findings, other agents with similar potential for induction of hepatic metabolism should be expected to participate in the interaction.

MANAGEMENT: During concomitant therapy with certain anticonvulsants, patients should be observed for potentially inadequate or altered response to teniposide, and the dosage adjusted accordingly as necessary.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Teniposide

Generic Name: teniposide

Brand name: Vumon

Synonyms: n.a.

What is Teniposide?