Equetro and Upadacitinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of upadacitinib, which is primarily metabolized by the isoenzyme. The interaction may result in loss of or reduced clinical response. In study subjects, administration with the potent CYP450 3A4 inducer rifampin decreased upadacitinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 61%, respectively. MANAGEMENT: The use of upadacitinib in combination with potent CYP450 3A4 inducers should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible. References "Product Information. Rinvoq (upadacitinib)." AbbVie US LLC, North Chicago, IL.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of upadacitinib, which is primarily metabolized by the isoenzyme. The interaction may result in loss of or reduced clinical response. In study subjects, administration with the potent CYP450 3A4 inducer rifampin decreased upadacitinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 61%, respectively.

MANAGEMENT: The use of upadacitinib in combination with potent CYP450 3A4 inducers should generally be avoided. Alternative agents with no or minimal CYP450 3A4 induction potential are recommended whenever possible.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

Upadacitinib

Generic Name: upadacitinib

Brand name: Rinvoq

Synonyms: n.a.

What is Upadacitinib?