Eravacycline Dihydrochloride and Oxacillin Sodium

• Generic Name: eravacycline
• Dosage Forms: n.a.
• Other Brand Names: Xerava

Eravacycline dihydrochloride is a tetracycline class antibacterial indicated for the treatment of complicated intra-abdominal infections (cIAI) in patients 18 years of age and older.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of eravacycline dihydrochloride and other antibacterial drugs, eravacycline dihydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Eravacycline dihydrochloride is not indicated for the treatment of complicated urinary tract infections (cUTI).

• Generic Name: oxacillin
• Dosage Forms: n.a.
• Other Brand Names:

  Oxacillin Sodium ADD-Vantage, Bactocill

Treatment of infections caused by, or suspected of being caused by, susceptible penicillinase-producing staphylococci, including respiratory tract, skin and skin structure, bone and joint, and urinary tract infections and meningitis or bacteremia. A drug of choice for these infections.

Treatment of native valve or prosthetic valve endocarditis caused by susceptible staphylococci. A drug of choice; used with or without gentamicin for native valve endocarditis and used in conjunction with rifampin and gentamicin for prosthetic valve endocarditis.

If used empirically, consider whether staphylococci resistant to penicillinase-resistant penicillins (oxacillin-resistant [methicillin-resistant] staphylococci) are prevalent in the hospital or community. (See Staphylococci Resistant to Penicillinase-resistant Penicillins under Cautions.)

Has been used for perioperative prophylaxis in patients undergoing neurosurgery or cardiovascular or orthopedic surgery associated with high risk of staphylococcal infections. Not considered a drug of choice.