Erdafitinib and Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide
Determining the interaction of Erdafitinib and Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies. MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. References "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Professional:GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided.
- "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Generic Name: amlodipine / hydrochlorothiazide / olmesartan
Brand name: Tribenzor
Synonyms: Amlodipine, hydrochlorothiazide, and olmesartan, Olmesartan, Amlodipine, and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erdafitinib-Olmesartan, Amlodipine, and Hydrochlorothiazide
- Erdafitinib-Olodaterol
- Erdafitinib-Olodaterol and tiotropium
- Erdafitinib-Olodaterol Hydrochloride
- Erdafitinib-Olodaterol inhalation
- Erdafitinib-Olopatadine nasal
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Erelzi Prefilled Syringe
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Erelzi Sensoready Pen
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Erelzi Subcutaneous
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Ergocalciferol
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Ergocalciferol Capsules and Tablets
- Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide-Ergocalciferol Solution