Erdafitinib and Sandimmune (Cyclosporine Oral Solution)
Determining the interaction of Erdafitinib and Sandimmune (Cyclosporine Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with erdafitinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter, resulting in increased toxicity of these drugs. In vitro, erdafitinib has been shown to be an inhibitor of P-gp. However, no pharmacokinetic data are available from drug interaction studies. MANAGEMENT: Concomitant use of erdafitinib and P-gp substrates should generally be avoided. If concomitant use is required, administer erdafitinib at least 6 hours before or after administration of P-gp substrates with narrow therapeutic ranges. References "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Professional:GENERALLY AVOID: Coadministration with erdafitinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter, resulting in increased toxicity of these drugs. In vitro, erdafitinib has been shown to be an inhibitor of P-gp. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of erdafitinib and P-gp substrates should generally be avoided. If concomitant use is required, administer erdafitinib at least 6 hours before or after administration of P-gp substrates with narrow therapeutic ranges.
- "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection), Sandimmune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erdafitinib-Sandimmune (Cyclosporine Soft Gelatin Capsules)
- Erdafitinib-Sandimmune Oral
- Erdafitinib-Sandostatin
- Erdafitinib-Sandostatin LAR
- Erdafitinib-Sandostatin LAR Depot
- Erdafitinib-Sandostatin LAR Depot injection
- Sandimmune (Cyclosporine Oral Solution)-Erelzi Prefilled Syringe
- Sandimmune (Cyclosporine Oral Solution)-Erelzi Sensoready Pen
- Sandimmune (Cyclosporine Oral Solution)-Erelzi Subcutaneous
- Sandimmune (Cyclosporine Oral Solution)-Ergocalciferol
- Sandimmune (Cyclosporine Oral Solution)-Ergocalciferol Capsules and Tablets
- Sandimmune (Cyclosporine Oral Solution)-Ergocalciferol Solution