Erdafitinib and Tacrolimus Extended-Release Tablets
Determining the interaction of Erdafitinib and Tacrolimus Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies. MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. References "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Professional:GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided.
- "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erdafitinib-Tacrolimus Granules for Suspension
- Erdafitinib-Tacrolimus Injection
- Erdafitinib-Tacrolimus Intravenous
- Erdafitinib-Tacrolimus oral and injection
- Erdafitinib-Tacrolimus Oral, Intravenous
- Erdafitinib-Tactinal
- Tacrolimus Extended-Release Tablets-Erelzi Prefilled Syringe
- Tacrolimus Extended-Release Tablets-Erelzi Sensoready Pen
- Tacrolimus Extended-Release Tablets-Erelzi Subcutaneous
- Tacrolimus Extended-Release Tablets-Ergocalciferol
- Tacrolimus Extended-Release Tablets-Ergocalciferol Capsules and Tablets
- Tacrolimus Extended-Release Tablets-Ergocalciferol Solution