Erdafitinib and Tezacaftor and Ivacaftor
Determining the interaction of Erdafitinib and Tezacaftor and Ivacaftor and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies. MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. References "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Professional:GENERALLY AVOID: Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity or decreased efficacy of these drugs. In vitro, erdafitinib has been shown to be a time-dependent inhibitor as well as inducer of CYP450 3A4. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Concomitant use of erdafitinib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided.
- "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Generic Name: ivacaftor / tezacaftor
Brand name: Symdeko, Symdeko 4-Week
Synonyms: Ivacaftor and tezacaftor
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erdafitinib-Tezacaftor/ivacaftor and ivacaftor
- Erdafitinib-TGQ 30PSE/3BRM/15DM
- Erdafitinib-TGQ 7.5PEH/4BRM/15DM
- Erdafitinib-TGT First Aid Antibiotic
- Erdafitinib-TGT First Aid Cleansing
- Erdafitinib-TH Antibiotic + Pain Relief
- Tezacaftor and Ivacaftor-Erelzi Prefilled Syringe
- Tezacaftor and Ivacaftor-Erelzi Sensoready Pen
- Tezacaftor and Ivacaftor-Erelzi Subcutaneous
- Tezacaftor and Ivacaftor-Ergocalciferol
- Tezacaftor and Ivacaftor-Ergocalciferol Capsules and Tablets
- Tezacaftor and Ivacaftor-Ergocalciferol Solution