Erleada and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Apalutamide may reduce the blood levels and effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

GENERALLY AVOID: Apalutamide and Enzalutamide may reduce the effects of oral anticoagulants. The proposed mechanism is induction of the enzyme CYP450 2C9. Induction of this enzyme by enzalutamide in prostate cancer patients has been shown to reduce the systemic exposure (AUC) of S-warfarin by 56%. Similarly, apalutamide has been reported to decrease S-warfarin AUC by 46%. The reduction in plasma concentration may lead to a loss of clinical effect.

MANAGEMENT: Concomitant use of apalutamide or enzalutamide with warfarin and coumarin-like anticoagulants should be avoided. If concomitant therapy is required, additional INR monitoring should be conducted and anticoagulant dosage adjusted accordingly, particularly following initiation, discontinuation, or change of dosage of enzalutamide in patients who are stabilized on their anticoagulant regimen. Patients should be monitored for altered anticoagulation and advised to promptly report any signs of blood clots (e.g., chest pain, shortness of breath, and sudden loss of vision, or pain, redness or swelling in an extremity) to their physician.

Erleada

Generic Name: apalutamide

Brand name: Erleada

Synonyms: n.a.

What is Erleada?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?