Erleada and Trametinib Dimethyl Sulfoxide
Determining the interaction of Erleada and Trametinib Dimethyl Sulfoxide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Apalutamide may decrease the blood levels and effects of trametinib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with apalutamide may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 3A4, 2C9, 2C19, breast cancer resistance protein (BCRP), uridine diphosphate glucuronosyltransferase (UGT), organic anion transporting polypeptide 1B1 (OATP1B1), and/or P-glycoprotein (P-gp) efflux transporter. The proposed mechanism involves accelerated clearance via these routes due to apalutamide-mediated induction. The resulting plasma concentrations will depend on the sensitivity of the affected drugs to these isoenzymes.
MANAGEMENT: Caution is advised when apalutamide is used concomitantly with drugs that are substrates of CYP450 3A4, 2C9, 2C19, BCRP, UGT, OATP1B1, and/or P-gp, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever apalutamide is added to or withdrawn from therapy.
- "Product Information. Erleada (apalutamide)." Janssen Biotech, Inc., Horsham, PA, PA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: trametinib
Brand name: Mekinist
Synonyms: Trametinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erleada-Trancot
- Erleada-Trandate
- Erleada-Trandate (Labetalol Injection)
- Erleada-Trandate (Labetalol Tablets)
- Erleada-Trandate Injection
- Erleada-Trandate Intravenous
- Trametinib Dimethyl Sulfoxide-Erlotinib
- Trametinib Dimethyl Sulfoxide-Erlotinib Tablets
- Trametinib Dimethyl Sulfoxide-Errin
- Trametinib Dimethyl Sulfoxide-Ertapenem
- Trametinib Dimethyl Sulfoxide-Ertapenem Injection
- Trametinib Dimethyl Sulfoxide-Ertapenem Sodium