Erlotinib and Fluvoxamine Tablets
Determining the interaction of Erlotinib and Fluvoxamine Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:FluvoxaMINE may increase the blood levels of erlotinib. You may need a dose adjustment if you have been taking erlotinib and are starting treatment with fluvoxaMINE. Let your doctor know if you experience severe or persistent diarrhea, nausea, vomiting, loss of appetite, skin rash, shortness of breath, cough, or fever while taking these medications, as they may be symptoms caused by increased effects of erlotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with an inhibitor of both CYP450 1A2 and 3A4 such as ciprofloxacin may significantly increase the plasma concentrations of erlotinib, which is a substrate of both isoenzymes. According to the product labeling, coadministration with ciprofloxacin increased erlotinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 17% and 39%, respectively, compared to administration of erlotinib alone.
MANAGEMENT: Caution is advised if erlotinib must be used with inhibitors of both CYP450 1A2 and 3A4. A dosage reduction or temporary interruption of therapy should be considered in patients who experience undue adverse effects of erlotinib such as severe diarrhea (i.e., that which is unresponsive to loperamide or results in dehydration), severe skin reactions, or severe liver function test abnormalities.
- "Product Information. Tarceva (erlotinib)." Genentech, South San Francisco, CA.
Generic Name: fluvoxamine
Brand name: Luvox, Luvox CR
Synonyms: Fluvoxamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erlotinib-Fluxid
- Erlotinib-Fluzone
- Erlotinib-Fluzone 2013-2014 Formula
- Erlotinib-Fluzone 2015-2016 Formula
- Erlotinib-Fluzone High Dose 2015-2016 Formula
- Erlotinib-Fluzone High-Dose
- Fluvoxamine Tablets-Erlotinib Tablets
- Fluvoxamine Tablets-Errin
- Fluvoxamine Tablets-Ertapenem
- Fluvoxamine Tablets-Ertapenem Injection
- Fluvoxamine Tablets-Ertapenem Sodium
- Fluvoxamine Tablets-Ertugliflozin