Erlotinib and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may reduce the blood levels of erlotinib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of erlotinib, which is primarily metabolized by the isoenzyme. According to the product labeling, erlotinib systemic exposure (AUC) may be reduced in the presence of the potent inducer rifampin by two-thirds to 80%, which is equivalent to a dose of about 30 to 50 mg in lung cancer patients. In one study, pretreatment with rifampin 600 mg daily for 7 days prior to erlotinib administration increased clearance of erlotinib by 3-fold and reduced AUC by 69%. In another study, pretreatment with rifampin for 11 days followed by a single 450 mg dose of erlotinib on day 8 resulted in a mean erlotinib AUC that was just 58% of that observed following a single 150 mg dose of erlotinib in the absence of rifampin treatment. No data are available for use with other, less potent CYP450 3A4 inducers.

MANAGEMENT: Alternative treatment lacking CYP450 3A4-inducing activity is recommended in patients receiving erlotinib. If alternative treatment is unavailable and a potent inducer (e.g., carbamazepine, enzalutamide, lumacaftor, mitotane, phenobarbital, phenytoin, primidone (partially metabolized to phenobarbital), rifamycins, St. John's wort) is to be used for more than a few days, an increase in the dosage of erlotinib should be considered as tolerated at 2-week intervals. Close clinical and laboratory monitoring for altered efficacy and safety, including renal and liver functions and serum electrolytes, is recommended. The maximum dosage of erlotinib studied in combination with rifampin is 450 mg. Patients who receive an increased dose of erlotinib will need a dosage reduction upon discontinuation of the inducer.

Erlotinib

Generic Name: erlotinib

Brand name: Tarceva

Synonyms: n.a.

What is Erlotinib?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?