Ertugliflozin and sitagliptin and Sandimmune
Determining the interaction of Ertugliflozin and sitagliptin and Sandimmune and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with cyclosporine, a potent inhibitor of P-glycoprotein efflux transporter, does not appear to significantly alter the pharmacokinetics of sitagliptin, which is a substrate of P-glycoprotein. Following coadministration of a single 100 mg oral dose of sitagliptin and a single 600 mg oral dose of cyclosporine, the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of sitagliptin were increased by 68% and 29%, respectively. These changes are not considered clinically significant. The renal clearance of sitagliptin was also not significantly altered in the presence of cyclosporine.
- "Product Information. Januvia (sitagliptin)." Merck & Company Inc, West Point, PA.
Generic Name: ertugliflozin / sitagliptin
Brand name: Steglujan
Synonyms: Ertugliflozin and Sitagliptin
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ertugliflozin and sitagliptin-Sandimmune (Cyclosporine Injection)
- Ertugliflozin and sitagliptin-Sandimmune (Cyclosporine Oral Solution)
- Ertugliflozin and sitagliptin-Sandimmune (Cyclosporine Soft Gelatin Capsules)
- Ertugliflozin and sitagliptin-Sandimmune Oral
- Ertugliflozin and sitagliptin-Sandostatin
- Ertugliflozin and sitagliptin-Sandostatin LAR
- Sandimmune-Erwinaze
- Sandimmune-Ery-Tab
- Sandimmune-Eryc
- Sandimmune-EryPed
- Sandimmune-EryPed 200
- Sandimmune-Eryped 200 Oral