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EryPed and Fluconazole Injection Solution

Determining the interaction of EryPed and Fluconazole Injection Solution and the possibility of their joint administration.

Check result:

EryPed <> Fluconazole Injection Solution

Relevance: 22.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using erythromycin together with fluconazole is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with either of these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with fluconazole may increase the plasma concentrations of erythromycin. The proposed mechanism is fluconazole inhibition of the CYP450 3A4-mediated metabolism of erythromycin. High dosages and plasma levels of erythromycin have been associated with QT interval prolongation and torsade de pointes arrhythmia. Fluconazole itself can also prolong the QT interval, thus an additive pharmacodynamic effect with erythromycin may occur as well.

MANAGEMENT: Coadministration of erythromycin with fluconazole is considered contraindicated.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM "Oral erythromycin and the risk of sudden death from cardiac causes." N Engl J Med 351 (2004): 1089-96
Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8
"Product Information. Diflucan (fluconazole)." Roerig Division, New York, NY.

EryPed

Generic Name: erythromycin

Brand name: E. E. S, EryPed, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: n.a.

What is EryPed?

Fluconazole Injection Solution

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

What is Fluconazole Injection Solution?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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