EryPed and Lomitapide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using lomitapide together with erythromycin is not recommended. Combining these medications may significantly increase the blood levels of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. You should seek prompt medical attention during treatment with lomitapide if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent and moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of lomitapide, which is primarily metabolized by the isoenzyme. When lomitapide (60 mg once daily) was coadministered with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 9 days), lomitapide peak plasma concentration (Cmax) increased by 15-fold and systemic exposure (AUC) increased by 27-fold compared to administration alone. Concomitant use with moderate CYP450 3A4 inhibitors has not been studied; however, significantly increased lomitapide exposure is similarly expected.

MANAGEMENT: Concomitant use of lomitapide with potent or moderate inhibitors of CYP450 3A4 is considered contraindicated.

EryPed

Generic Name: erythromycin

Brand name: E. E. S, EryPed, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: n.a.

What is EryPed?

Lomitapide

Generic Name: lomitapide

Brand name: Juxtapid

Synonyms: n.a.

What is Lomitapide?