Drug search by name

EryPed and Propulsid (Cisapride Suspension)

Determining the interaction of EryPed and Propulsid (Cisapride Suspension) and the possibility of their joint administration.

Check result:

EryPed <> Propulsid (Cisapride Suspension)

Relevance: 22.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cisapride together with erythromycin is not recommended. Combining these medications may significantly increase the blood levels and effects of cisapride. High blood levels of cisapride can occasionally cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with cisapride. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. **Cisapride (Propulsid) is no longer marketed in the United States. You should only be taking cisapride if you are obtaining the medication from your doctor though a Limited Access Program developed jointly by the manufacturer and the FDA.**

Professional:

CONTRAINDICATED: Coadministration with the ketolide, telithromycin, as well as certain macrolide antibiotics may significantly increase the plasma concentrations of cisapride. The mechanism is inhibition of cisapride metabolism via CYP450 3A4. High plasma levels of cisapride have been associated with prolongation of the QT interval on the ECG; ventricular arrhythmias including ventricular tachycardia, ventricular fibrillation, and torsade de pointes; cardiac arrest; and sudden death. Macrolides that may significantly inhibit CYP450 3A4 include clarithromycin, erythromycin, and troleandomycin. Azithromycin and dirithromycin are generally believed to have little, if any, effect on CYP450 3A4. In a study of 12 healthy volunteers, coadministration of clarithromycin (500 mg twice a day) and cisapride (10 mg four times a day) led to threefold increases in cisapride concentrations and an average QTc increase of 25 ms above pretreatment values. In contrast, monotherapy with cisapride was associated with a concentration-dependent QTc elevation that amounted to 6 ms during steady state. Repeated doses of telithromycin have been reported to increase steady-state cisapride peak plasma concentrations by 95%, resulting in significant increases in QTc interval.

MANAGEMENT: Given the potential for serious and life-threatening adverse cardiac events associated with increased plasma levels of cisapride, the use of cisapride with clarithromycin, erythromycin, troleandomycin, or telithromycin is considered contraindicated.

References

Desta Z, Soukhova N, Mahal SK, Flockhart DA "Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies." Drug Metab Dispos 28 (2000): 789-800
"Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ.
Sekkarie MA "Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin." Am J Kidney Dis 30 (1997): 437-9
Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251
Jenkins IR, Gibson J "Cisapride, erythromycin and arrhythmia." Anaesth Intensive Care 24 (1996): 728
Gray VS "Syncopal episodes associated with cisapride and concurrent drugs." Ann Pharmacother 32 (1998): 648-51
vanHaarst AD, vantKlooster GAE, vanGerven JMA, Schoemaker RC, vanOene JC, Burggraaf J, Coene MC, Cohen AF "The influence of cisapride and clarithromycin on QT intervals in healthy volunteers." Clin Pharmacol Ther 64 (1998): 542-6
Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81
Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57
Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112
Bran S, Murray WA, Hirsch IB, Palmer JP "Long QT syndrome during high-dose cisapride." Arch Intern Med 155 (1995): 765-8
Amsden GW "Macrolides versus azalides: a drug interaction update." Ann Pharmacother 29 (1995): 906-17
Vitola J, Vukanovic J, Roden DM "Cisapride-induced torsades de pointes." J Cardiovasc Electrophysiol 9 (1998): 1109-13
Piquette RK "Torsade de pointes induced by cisapride/clarithromycin interaction." Ann Pharmacother 33 (1999): 22-6
Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton DR, Berul CI "Proarrhythmia associated with cisapride in children." Pediatrics 101 (1998): 1053-6
Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75
European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) Available from: URL: http:www.emea.eu.int/humandocs/Humans/EPAR/Ketek/Ketek.htm." ([2001]):
"Product Information. Ketek (telithromycin)." Aventis Pharmaceuticals, Bridgewater, NJ.
Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75

EryPed

Generic Name: erythromycin

Brand name: E. E. S, EryPed, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: n.a.

What is EryPed?

Propulsid (Cisapride Suspension)

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Propulsid (Suspension), Propulsid

What is Propulsid (Cisapride Suspension)?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions