EryPed 200 and Zonisamide Capsules
Determining the interaction of EryPed 200 and Zonisamide Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Erythromycin may increase the blood levels and effects of zonisamide. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of zonisamide, which is metabolized by the isoenzyme. While clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of zonisamide should be considered.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy. Patients should be advised to notify their physician if they experience symptoms such as severe drowsiness, confusion, loss of coordination, depression, aphasia, decreased sweating, fever, loss of seizure control, or slow pulse.
- Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83
- "Product Information. Zonegran (zonisamide)" Elan Pharmaceuticals, S. San Francisco, CA.
Generic Name: erythromycin
Brand name: E. E. S, EryPed, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV
Synonyms: EryPed
Generic Name: zonisamide
Brand name: Zonegran
Synonyms: Zonisamide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- EryPed 200-Zontivity
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- EryPed 200-Zoo Friends Complete
- EryPed 200-Zoo Friends Gummies
- EryPed 200-Zorbtive
- EryPed 200-Zorcaine
- Zonisamide Capsules-Eryped 200 Oral
- Zonisamide Capsules-Eryped 400 Oral
- Zonisamide Capsules-Eryped Oral
- Zonisamide Capsules-Erythrocin
- Zonisamide Capsules-Erythrocin Injection
- Zonisamide Capsules-Erythrocin Injection USP