Erythromycin Ethyl Succinate Tablets and Retapamulin
Determining the interaction of Erythromycin Ethyl Succinate Tablets and Retapamulin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of retapamulin, which is primarily metabolized by the isoenzyme. In healthy adult males, coadministration of the potent CYP450 3A4 inhibitor ketoconazole (200 mg orally twice a day) increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of retapamulin by 81% following topical application of retapamulin ointment 1% on abraded skin. However, dosage adjustments are not necessary due to the low systemic exposure to retapamulin following topical application.
- "Product Information. Altabax (retapamulin topical)." GlaxoSmithKline, Research Triangle Park, NC.
Generic Name: erythromycin
Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV
Synonyms: Erythromycin, Erythromycin (Systemic)
Generic Name: retapamulin topical
Brand name: Altabax
Synonyms: Retapamulin topical
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erythromycin Ethyl Succinate Tablets-Retapamulin topical
- Erythromycin Ethyl Succinate Tablets-Retapamulin Topical application
- Erythromycin Ethyl Succinate Tablets-Retavase
- Erythromycin Ethyl Succinate Tablets-Retavase Half-Kit
- Erythromycin Ethyl Succinate Tablets-Reteplase
- Erythromycin Ethyl Succinate Tablets-Reteplase, recombinant Intravenous
- Retapamulin-Erythromycin Filmtabs
- Retapamulin-Erythromycin Injection
- Retapamulin-Erythromycin Intravenous
- Retapamulin-Erythromycin Lactobionate - I.V.
- Retapamulin-Erythromycin Oral Suspension
- Retapamulin-Erythromycin Suspension