Erythromycin Injection and Sodium Citrate and Citric Acid Oral Solution
Determining the interaction of Erythromycin Injection and Sodium Citrate and Citric Acid Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concurrent administration of antacids may prolong the elimination half-life of erythromycin. The mechanism of interaction is unknown. In eight healthy volunteers, administration of erythromycin stearate 500 mg followed immediately with 30 mL of antacid (aluminum hydroxide/magnesium hydroxide/simethicone 200 mg/200 mg/20 mg per 5 mL) resulted in a doubling of the mean elimination rate constant compared to administration of the erythromycin stearate alone. Coadministration with antacid had no effect on the peak serum concentration (Cmax), total area under the concentration-time curve (AUC), or time to peak concentration (Tmax) of erythromycin. These changes are unlikely to be of clinical importance, and no special precautions appear to be necessary.
- Yamreudeewong W, Scavone JM, Paone RP, Lewis GP "Effect of antacid coadministration on the bioavailability of erythromycin stearate." Clin Pharm 8 (1989): 352-4
Generic Name: erythromycin
Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV
Synonyms: Erythromycin, Erythromycin (Systemic)
Generic Name: citric acid / sodium citrate
Brand name: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit, Shohl's Solution, Virtrate-2
Synonyms: Citric acid and sodium citrate, Sodium Citrate and Citric Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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