Erythromycin Lactobionate - I.V. and Magnesium Oxide 400
Determining the interaction of Erythromycin Lactobionate - I.V. and Magnesium Oxide 400 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concurrent administration of antacids may prolong the elimination half-life of erythromycin. The mechanism of interaction is unknown. In eight healthy volunteers, administration of erythromycin stearate 500 mg followed immediately with 30 mL of antacid (aluminum hydroxide/magnesium hydroxide/simethicone 200 mg/200 mg/20 mg per 5 mL) resulted in a doubling of the mean elimination rate constant compared to administration of the erythromycin stearate alone. Coadministration with antacid had no effect on the peak serum concentration (Cmax), total area under the concentration-time curve (AUC), or time to peak concentration (Tmax) of erythromycin. These changes are unlikely to be of clinical importance, and no special precautions appear to be necessary.
- Yamreudeewong W, Scavone JM, Paone RP, Lewis GP "Effect of antacid coadministration on the bioavailability of erythromycin stearate." Clin Pharm 8 (1989): 352-4
Generic Name: erythromycin
Brand name: Erythromycin Lactobionate - IV, EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs
Synonyms: n.a.
Generic Name: magnesium oxide
Brand name: MagGel, Phillips' Cramp-free, Uro-Mag, Mag-200, Mag-Ox 400, UroMag, Mag-Oxide, Magnesium Oxide 400, MAGnesium-Oxide, Maox, Uro-Mag
Synonyms: Magnesium oxide, Magnesium Oxide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Erythromycin Lactobionate - I.V.-Magnesium salicylate
- Erythromycin Lactobionate - I.V.-Magnesium sulfate
- Erythromycin Lactobionate - I.V.-Magnesium Sulfate Granules (Epsom Salt)
- Erythromycin Lactobionate - I.V.-Magnesium Sulfate in Dextrose Injection
- Erythromycin Lactobionate - I.V.-Magnesium sulfate injection
- Erythromycin Lactobionate - I.V.-Magnesium sulfate Oral, Topical application, Route Not Applicable
- Magnesium Oxide 400-Erythromycin Oral Suspension
- Magnesium Oxide 400-Erythromycin Suspension
- Magnesium Oxide 400-Erythromycin Tablets
- Magnesium Oxide 400-Eryzole
- Magnesium Oxide 400-Esbriet
- Magnesium Oxide 400-Escavite