Escitalopram Oral Solution and Metoprolol Intravenous
Determining the interaction of Escitalopram Oral Solution and Metoprolol Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Escitalopram may increase the plasma concentrations of metoprolol. Administration of 20 mg/day escitalopram for 21 days resulted in a 50% increase of the maximum plasma concentration and an 82% increase of the AUC of metoprolol (single 100 mg dose); however, no clinically significant effects on blood pressure or heart rate occurred. The mechanism may be related to inhibition of CYP450 2D6 metabolism. Increased levels may decrease beta blocker cardioselectivity. It may be advisable to monitor patients for increased pharmacological effects of metoprolol.
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
Generic Name: escitalopram
Brand name: Lexapro
Synonyms: Escitalopram
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Escitalopram Oral Solution-Metoprolol Succinate
- Escitalopram Oral Solution-Metoprolol Succinate ER Capsules
- Escitalopram Oral Solution-Metoprolol Succinate ER Tablets
- Escitalopram Oral Solution-Metoprolol Tablets
- Escitalopram Oral Solution-Metoprolol Tartrate
- Escitalopram Oral Solution-Metoprolol Tartrate and Hydrochlorothiazide
- Metoprolol Intravenous-Escitalopram Oxalate
- Metoprolol Intravenous-Escitalopram Solution
- Metoprolol Intravenous-Escitalopram Tablets
- Metoprolol Intravenous-Esclim Transdermal
- Metoprolol Intravenous-Eserine
- Metoprolol Intravenous-Esgic