Escitalopram Solution and Metoprolol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Escitalopram may increase the plasma concentrations of metoprolol. Administration of 20 mg/day escitalopram for 21 days resulted in a 50% increase of the maximum plasma concentration and an 82% increase of the AUC of metoprolol (single 100 mg dose); however, no clinically significant effects on blood pressure or heart rate occurred. The mechanism may be related to inhibition of CYP450 2D6 metabolism. Increased levels may decrease beta blocker cardioselectivity. It may be advisable to monitor patients for increased pharmacological effects of metoprolol.

Escitalopram Solution

Generic Name: escitalopram

Brand name: Lexapro

Synonyms: Escitalopram

What is Escitalopram Solution?

Metoprolol

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: n.a.

What is Metoprolol?