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Eskalith and Isoptin SR

Determining the interaction of Eskalith and Isoptin SR and the possibility of their joint administration.

Check result:

Eskalith <> Isoptin SR

Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking verapamil, tell your doctor if you also use lithium. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter your lithium levels. You should notify your doctor if you have symptoms such as diarrhea, vomiting, drowsiness, tremor, thirst, lack of coordination, or muscle weakness. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Verapamil has variable effects on lithium levels. Increases, decreases, and no change in serum lithium levels have all been reported. The mechanism is unknown.

MANAGEMENT: Patients who must take both drugs should be monitored for evidence of lithium toxicity. Patients should be advised to notify their physician if they experience symptoms of possible lithium toxicity such as drowsiness, dizziness, confusion, ataxia, vomiting, diarrhea, thirst, blurry vision, tinnitus, or tremor.

References

Helmuth D, Ljaljevic Z, Ramirez L, Meltzer HY "Choreoathetosis induced by verapamil and lithium treatment." J Clin Psychopharmacol 9 (1989): 454-5
Price WA, Shalley JE "Lithium-verapamil toxicity in the elderly." J Am Geriatr Soc 35 (1987): 177-9
Chandragiri SS, Pasol E, Gallagher RM "Lithium, ACE inhibitors, NSAIDs, and verapamil - A possible fatal combination." Psychosomatics 39 (1998): 281-2
Weinrauch LA, Belok S, D'Elia JA "Decreased serum lithium during verapamil therapy." Am Heart J 108 (1984): 1378-80
Price WA, Giannini AJ "Lithium-verapamil: further considerations." J Clin Psychiatry 48 (1987): 124
McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76
Wright BA, Jarrett DB "Lithium and calcium channel blockers: possible neurotoxicity." Biol Psychiatry 30 (1991): 635-6
Price WA, Giannini AJ "Neurotoxicity caused by lithium-verapamil synergism." J Clin Pharmacol 26 (1986): 717-9
Dubovsky SL, Franks RD, Allen S "Verapamil: a new antimanic drug with potential interactions with lithium." J Clin Psychiatry 48 (1987): 371-2

Eskalith

Generic Name: lithium

Brand name: Eskalith, Lithobid, Lithonate, Lithotabs, Eskalith-CR

Synonyms: n.a.

What is Eskalith?

Isoptin SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Isoptin SR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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