Eskalith and MetroGel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking lithium, tell your doctor if you also use metroNIDAZOLE topical. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase your lithium levels. You should notify your doctor if you have symptoms such as diarrhea, vomiting, drowsiness, tremor, thirst, lack of coordination, or muscle weakness. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Limited data suggest that coadministration with metronidazole may increase the risk of lithium toxicity. The mechanism of interaction has not been described, and it is not known whether the interaction occurs with other nitroimidazoles or vaginally administered metronidazole. In one case report, two patients who had been stabilized on lithium therapy developed suspected lithium toxicity shortly (12 to 19 days) after the addition of a one-week course of metronidazole for the treatment of vaginitis. One patient had increased serum creatinine and lithium levels that remained elevated for a protracted length of time, accompanied by complaints of polyuria and nocturia. The lithium dosage was reduced, which led to a decrease in symptoms and serum lithium levels. However, serum creatinine remained elevated five months after metronidazole treatment was completed. In the other patient, serum creatinine and sodium were increased in the absence of significantly elevated serum lithium levels. However, lithium was discontinued due to symptoms of confusion.

MANAGEMENT: Pharmacologic response and serum lithium levels should be monitored more closely whenever metronidazole is added to or withdrawn from therapy, and the lithium dosage adjusted as necessary. Patients should be advised to notify their physician if they experience early symptoms of lithium toxicity such as diarrhea, vomiting, drowsiness, tremor, lack of coordination, ataxia, or muscular weakness. The same precaution may be applicable during therapy with tinidazole or vaginal preparations of metronidazole, although clinical data are lacking.

Eskalith

Generic Name: lithium

Brand name: Eskalith, Lithobid, Lithonate, Lithotabs, Eskalith-CR

Synonyms: n.a.

What is Eskalith?

MetroGel

Generic Name: metronidazole topical

Brand name: MetroCream, MetroGel, MetroGel Pump, MetroLotion, Noritate, Rosadan, MetroGel-Vaginal, Nuvessa, Vandazole

Synonyms: n.a.

What is MetroGel?