Esketamine and Triaminic Day Time Cold & Cough
Determining the interaction of Esketamine and Triaminic Day Time Cold & Cough and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using esketamine together with dextromethorphan may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. After receiving treatment with esketamine, you should avoid driving or operating hazardous machinery until the next day after a restful sleep. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of esketamine with central nervous system (CNS) depressants may increase sedation and impairment of attention, judgment, thinking, reaction speed, and psychomotor skills. In clinical trials, 49% to 61% of esketamine-treated patients developed sedation based on the
Modified Observer's Alertness/Sedation scale (MOAA/s), and 0.3% of esketamine-treated patients experienced loss of consciousness (MOAA/s score of 0). In the MOAA/s scale, 5 means "responds readily to name spoken in normal tone" and 0 means "no response after painful trapezius squeeze," and any decrease in MOAA/s from pre-dosing of esketamine is considered to indicate presence of sedation. Dose-related increases in the incidence of sedation were observed in a fixed-dose study.
MANAGEMENT: Caution is advised and patients should be closely monitored during concomitant use of esketamine with CNS depressants. Due to the risk of delayed or prolonged sedation and other adverse effects, patients should be monitored for at least 2 hours after esketamine administration, followed by an assessment to determine when the patient is considered clinically stable and ready to leave the healthcare setting. Patients should be instructed not to engage in potentially hazardous activities, such as driving a motor vehicle or operating machinery, until the next day after a restful sleep.
- "Product Information. Spravato (esketamine)." Janssen Pharmaceuticals, Titusville, NJ.
Generic Name: esketamine
Brand name: Spravato
Synonyms: Esketamine (nasal)
Generic Name: dextromethorphan / phenylephrine
Brand name: Children's Triacting Daytime, PediaCare Children's Multi-Symptom Cold, Safetussin CD, Sudafed PE Children's Cold & Cough, Triaminic Day Time Cold & Cough, Albatussin Pediatric, Pedia Care Multi-Symptom Cold, PediaCare Childrenâs Multi-Symptom, Sudafed PE Cold & Cough Child, Triacting Day Time Cold/Cough, Vicks Formula 44D Cough & Sinus Congestion Relief, Triaminic Daytime Cough & Cold, Triaminic Thin Strips Cough and Congestion, Triaminic Toddler Cough and Cold Thin Strips, Dimetapp Cold & Cough, Triaminic Thin Strips Infant Decongestant Plus Cough, PediaCare Infant Decongestant & Cough
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Esketamine-Triaminic Day Time Night Time Cold & Cough
- Esketamine-Triaminic Decongestant
- Esketamine-Triaminic Decongestant/Cough Infant
- Esketamine-Triaminic Fever Reducer
- Esketamine-Triaminic Flu Cough & Fever
- Esketamine-Triaminic Long Acting Cough
- Triaminic Day Time Cold & Cough-Esketamine Hydrochloride
- Triaminic Day Time Cold & Cough-Esketamine nasal
- Triaminic Day Time Cold & Cough-Eslicarbazepine
- Triaminic Day Time Cold & Cough-Eslicarbazepine Acetate
- Triaminic Day Time Cold & Cough-Esmolol
- Triaminic Day Time Cold & Cough-Esmolol HCl