Esketamine Hydrochloride and Fenoprofen Calcium

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: fenoprofen
• Dosage Forms: n.a.
• Other Brand Names: Nalfon, ProFeno, Fenortho, ProFeno

Consider potential benefits and risks of fenoprofen therapy as well as alternative therapies before initiating therapy with the drug. Use lowest possible effective dosage and shortest duration of therapy consistent with patient’s treatment goals.

Relief of mild to moderate pain in adults.

Symptomatic treatment of osteoarthritis and rheumatoid arthritis.

Has been used in the symptomatic treatment of juvenile rheumatoid arthritis.

Also has been used with some success in the treatment of ankylosing spondylitis and acute gouty arthritis.