Esketamine Hydrochloride and Granisetron

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: granisetron
• Dosage Forms: n.a.
• Other Brand Names: Sustol, Kytril, Sancuso

Granisetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Granisetron is used to prevent nausea and vomiting that may be caused by medicine to treat cancer (chemotherapy or radiation).

Granisetron may also be used for purposes not listed in this medication guide.