Esketamine Hydrochloride and Hydrochlorothiazide and propranolol

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: hydrochlorothiazide / propranolol
• Dosage Forms: n.a.
• Other Brand Names: Inderide, Inderide LA

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Hydrochlorothiazide and propranolol is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and propranolol may also be used for purposes not listed in this medication guide.