Esketamine Hydrochloride and Insulin NPH

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: insulin isophane
• Dosage Forms: n.a.
• Other Brand Names: Humulin N, HumuLIN N KwikPen, Novolin N, ReliOn/NovoLIN N, Insulin Purified NPH Pork, Iletin II NPH Pork, Iletin NPH, HumuLIN N Pen, NovoLIN N PenFill, NovoLIN N Innolet, Humulin N, Novolin N

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin isophane is an intermediate-acting insulin that starts to work within 2 to 4 hours after injection, peaks in 4 to 12 hours, and keeps working for 12 to 18 hours.

Insulin isophane is used to improve blood sugar control in adults and children with diabetes mellitus.

Insulin isophane may also be used for purposes not listed in this medication guide.