Esketamine Hydrochloride and Phenylephrine and Pyrilamine Liquid
Determining the interaction of Esketamine Hydrochloride and Phenylephrine and Pyrilamine Liquid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:It is not known how esketamine and phenylephrine nasal may affect each other when they are used at the same time. If you need to use phenylephrine nasal on a day when dosing of esketamine is scheduled, you should use it at least one hour before esketamine. Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Data are limited with respect to any potential interaction between intranasal esketamine and other nasal products during concomitant administration. In pharmacokinetic studies, mometasone furoate and oxymetazoline hydrochloride administered intranasally one hour before esketamine demonstrated no clinically significant effects on esketamine peak plasma concentration and exposure.
MANAGEMENT: To minimize the risk of interaction, patients who require a nasal corticosteroid or nasal decongestant on a day when esketamine dosing is scheduled should administer these medications at least one hour before esketamine.
- "Product Information. Spravato (esketamine)." Janssen Pharmaceuticals, Titusville, NJ.
Generic Name: esketamine
Brand name: Spravato
Synonyms: Esketamine (nasal), Esketamine
Generic Name: phenylephrine / pyrilamine nasal
Brand name: Ru-Hist-D
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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