Esketamine Hydrochloride and Procto-Kit 2.5% cream, ointment, suppository

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: hydrocortisone topical
• Dosage Forms: n.a.
• Other Brand Names:

  Anucort-HC, Anumed-HC, Anusol-HC, Cortizone-10 Anal Itch Cream, Hemorrhoidal HC, Hemril-30, Hemril-HC Uniserts, Preparation H Hydrocortisone, Procto-Kit 1%, Procto-Kit 25%, Procto-Pak 1%, Proctocort, Proctocream-HC, Proctosert HC, Proctosol-HC, Proctozone HC, Proctozone-H, Recort Plus, Rectasol-HC, Tucks HC, Ala-Cort, Aquanil HC, Beta HC, Cortizone-5, Dermarest Plus Anti-Itch, Dermasorb HC, Dermtex HC, Gynecort Maximum Strength, Hydro Skin, Instacort, Itch-X Lotion, Locoid, Pandel, Pediaderm HC, Sarnol-HC, Cortizone-10, ProctoCare-HC

Hydrocortisone is a steroid medicine that reduces inflammation in the body.

The information in this medication guide is specific to Procto-Kit 2.5% cream, ointment, or suppository.

Procto-Kit 2.5% is used to treat itching or swelling caused by hemorrhoids or other inflammatory conditions of the rectum or anus.

Procto-Kit 2.5% is also used together with other medications to treat ulcerative colitis, proctitis, and other inflammatory conditions of the lower intestines and rectal area.

Procto-Kit 2.5% may also be used for purposes not listed in this medication guide.