Esketamine Hydrochloride and Tolbutamide

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: tolbutamide
• Dosage Forms: n.a.
• Other Brand Names:

  Orinase, Orinase Diagnostic, Tol-Tab

Tolbutamide causes the pancreas to produce insulin and increases your body's response to it.

Tolbutamide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Tolbutamide is not for treating type 1 diabetes.

Tolbutamide may also be used for purposes not listed in this medication guide.