Esketamine Hydrochloride and Zylet ophthalmic

• Generic Name: esketamine
• Dosage Forms: n.a.
• Other Brand Names: Spravato

Used intranasally for treatment (in combination with an oral antidepressant) of treatment-resistant depression. Although there are various definitions of treatment-resistant depression, the condition is often defined as the failure of ≥2 trials of first-line antidepressants given in an adequate dosage for an adequate duration of therapy.

Intranasal esketamine substantially improved depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) within 24 hours of administration in a short-term clinical trial and prolonged time to relapse in a longer-term maintenance trial.

Esketamine is the S-enantiomer of racemic ketamine, which is an anesthetic agent. However, esketamine is not labeled for use as an anesthetic agent; efficacy and safety not established.

• Generic Name: loteprednol / tobramycin ophthalmic
• Dosage Forms: ophthalmic suspension
• Other Brand Names: Zylet

Loteprednol and tobramycin ophthalmic (for the eyes) is a combination antibiotic and steroid medicine that is used to treat eye inflammation caused by allergies, shingles (herpes zoster), severe acne, iritis, uveitis, eye injury, radiation, chemical burns, or certain other conditions.

This medicine is used when there is a risk of bacterial infection in or around the eye.

Loteprednol and tobramycin ophthalmic may also be used for purposes not listed in this medication guide.