Eslicarbazepine and Ezallor Sprinkle
Determining the interaction of Eslicarbazepine and Ezallor Sprinkle and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Eslicarbazepine may reduce the blood levels and effects of rosuvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with eslicarbazepine acetate may decrease the plasma concentrations of rosuvastatin. The exact mechanism of interaction has not been established, but may involve eslicarbazepine induction of the metabolism of rosuvastatin via UDP-glucuronyl transferase. In healthy study subjects, rosuvastatin systemic exposure (AUC) decreased by an average of 36% to 39% when coadministered with eslicarbazepine acetate 1200 mg once daily.
MANAGEMENT: The potential for diminished therapeutic effects of rosuvastatin should be considered when prescribed in combination with eslicarbazepine acetate. A dosage increase for rosuvastatin may be required based on efficacy and tolerability.
- "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc, Marlborough, MA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: eslicarbazepine
Brand name: Aptiom
Synonyms: n.a.
Generic Name: rosuvastatin
Brand name: Crestor, Ezallor Sprinkle
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Eslicarbazepine-EZChar
- Eslicarbazepine-Ezetimibe
- Eslicarbazepine-Ezetimibe and simvastatin
- Eslicarbazepine-Ezetimibe and Simvastatin Tablets
- Eslicarbazepine-Ezfe
- Eslicarbazepine-EZFE 200
- Ezallor Sprinkle-Eslicarbazepine Acetate
- Ezallor Sprinkle-Esmolol
- Ezallor Sprinkle-Esmolol HCl
- Ezallor Sprinkle-Esmolol Hydrochloride
- Ezallor Sprinkle-Esmolol Injection
- Ezallor Sprinkle-Esmolol Intravenous