Eslicarbazepine and Zohydro ER Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Eslicarbazepine may reduce the blood levels of HYDROcodone, which may make the medication less effective in treating your pain. Additionally, if you have been receiving treatment with HYDROcodone, adding eslicarbazepine may cause you to experience unpleasant withdrawal symptoms such as watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heart beat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss. On the other hand, if you have been receiving both medications, discontinuing eslicarbazepine may increase the blood levels of HYDROcodone, which could lead to an overdose. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, you should avoid driving or operating hazardous machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with enzyme-inducing anticonvulsants may decrease the plasma concentrations of opioids that are primarily metabolized by CYP450 3A4 such as butorphanol, fentanyl, hydrocodone, and oxycodone. Reduced efficacy or withdrawal symptoms may occur in patients maintained on their narcotic pain regimen following the addition of an enzyme-inducing anticonvulsant. Conversely, discontinuation of the anticonvulsant may increase opioid plasma concentrations and potentiate the risk of overdose and fatal respiratory depression.

MANAGEMENT: Pharmacologic response to the opioid should be monitored more closely whenever an enzyme-inducing anticonvulsant is added to or withdrawn from therapy, and the opioid dosage adjusted as necessary. Due to the potential for additive central nervous system depressant effects, ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them.

Eslicarbazepine

Generic Name: eslicarbazepine

Brand name: Aptiom

Synonyms: n.a.

What is Eslicarbazepine?

Zohydro ER Capsules

Generic Name: hydrocodone

Brand name: Hysingla ER, Zohydro ER, Vantrela ER

Synonyms: Hydrocodone

What is Zohydro ER Capsules?